Nope. RegisterServerEvent is the old and deprecated name for RegisterNetEvent.
Over the network events are events that can be triggered…well…over the network. So, server events that can be triggered from the client, and vice-versa. They are the main communication line between server and client scripts.
Just don’t trust the client. There are a lot to talk about securing scripts against lua executors, but the main point is: Client should not decide data change!
This topic is still valid: How hackers can exploit your servers and what to do about it